THE SUCCESSFUL USE OF HYPERSTIMULATED WASHED THERAPEUTIC DONOR INSEMINATION AFTER STANDARD THERAPEUTIC DONOR INSEMINATION HAS FAILED

To investigate whether an aggressive therapeutic donor insemination re gimen (stimulated folliculogenesis and ovulation plus intrauterine ins emination) can produce a better fecundability rate than a more traditi onal insemination regimen (non-stimulated folliculogenesis plus LH-tim ed intracervical insemination) in women who have failed to become preg nant during an initial series of six traditional insemination cycles. Design-A retrospective comparison of fecundability rates was undertake n between women undergoing the traditional insemination protocol and t hose who voluntarily switched to ovarian hyperstimulation coupled with intrauterine insemination. Participants-Eight-two women who failed to become pregnant during an initial series of six intracervical insemin ation cycles. Results-Fecundability was 5.6% in cycles of continued ur inary LH-timed intracervical insemination and 19.4% when the more aggr essive regimen was applied. The difference in fecundability between pr otocols was significant (P<.005). Conclusion-After an initial series o f donor inseminations has failed, a more aggressive insemination regim en involving ovarian hyperstimulation followed by washed intrauterine insemination provides a higher fecundability rate than continued intra cervical insemination.