STEWART-TREVES SYNDROME - IMMUNOHISTOCHEM ISTRY TESTS IN 2 CASES

Two women (63 and 68 years) presented with primary angiosarcomas of th e skin which had developed on an area of chronic lymphoedema after rad iosurgical treatment for breast cancer 4 and 13 years earlier. Immunoh istochemistry tests formally eliminated epithelial metastasis and prod uced evidence in favour of lymphatic or capillary vascular proliferati on. Endothelial affinity for anti-factor VIII and positive tests for c ertain markers of intermediary filaments (actin, vimentin) confirmed t he vascular and conjunctive tissue origin of the tumours.