S. Faranda et al., THE HUMAN GENES ENCODING RENIN-BINDING PROTEIN AND HOST-CELL FACTOR ARE CLOSELY LINKED IN XQ28 AND TRANSCRIBED IN THE SAME DIRECTION, Gene, 155(2), 1995, pp. 237-239
The Xq28 chromosomal band represents a C + G-rich region onto which se
veral genes have been mapped. In most cases, the exact relationship be
tween the mapped genes has not yet been established, and neither the r
egulatory nor the spacer regions between the various transcription uni
ts have been defined, In the region around the L1CAM gene (encoding L1
cell adhesion molecule), the transcription units appear, from prelimi
nary analyses, to be quite compact. By sequencing the region at the 3'
end of the recently found host cell factor 1-encoding gene (HCFC1), w
e report that the renin-binding protein-encoding gene (REP) major tran
scription start point lies 2763 bp downstream from the 3' end of HCFC1
and that both are transcribed in the same direction from the telomere
to the centromere.