NEGATIVE REGULATION OF IMMEDIATE-EARLY GENE-EXPRESSION OF PSEUDORABIES VIRUS BY INTERFERON-ALPHA

Authors
TONOMURA N ONO E SHIMIZU Y KIDA H
Citation
N. Tonomura et al., NEGATIVE REGULATION OF IMMEDIATE-EARLY GENE-EXPRESSION OF PSEUDORABIES VIRUS BY INTERFERON-ALPHA, Veterinary microbiology, 53(3-4), 1996, pp. 271-281
Citations number
37
Categorie Soggetti
Microbiology,"Veterinary Sciences
Journal title
Veterinary microbiology → ACNP
ISSN journal
03781135
Volume
53
Issue
3-4
Year of publication
1996
Pages
271 - 281
Database
ISI
SICI code
0378-1135(1996)53:3-4<271:NROIGO>2.0.ZU;2-6
Abstract
Pseudorabies virus (PrV) replication in Vero cells was suppressed by t reatment with human natural interferon-alpha (IFN-alpha). Messenger RN A transcribed from the PrV immediate-early (IE) gene was reduced in th e IFN-alpha-treated cells, Transient expression assays showed that tra nscription from the PrV IE promoter was selectively inhibited in the I FN-alpha-treated cells. Analysis of deletion mutants of the PrV LE pro moter sequence suggested that at least one element between the transcr iption initiation site (+1) and -90 in the PrV IE promoter was concern ed with the negative regulation.