Interpretation of the meaning of differences between the Mental Develo
pmental Index (MDI) and Psychomotor Developmental Index (PDI) of the B
ayley Scales of Infant Development is unclear. Herein, the relationshi
p between MDI/PDI scores in 517 infants is evaluated at 6, 12, and 24
months in terms of levels of socioeconomic status (SES), biological ri
sk, degree of prematurity, and cognitive ability level (AL). The relat
ionship between MDI and PDI scores also is compared in a longitudinal
sample of 224 children. Socioeconomic status did not influence the rel
ationship between MDI and PDI scores, biologic risk affected the relat
ionship between MDI and PDI only at 6 months, and MDI/PDI difference s
cores varied depending on AL throughout infancy. At higher levels of c
ognitive function, the MDI routinely was greater than the PDI; at lowe
r cognitive levels, the reverse was true. Correlations between differe
nce scores over time and difference score reliability (relationship be
tween MDI and PDI at each age) generally were weak. Instability and me
asurement error underscore the need for caution in interpretation of M
DI/PDI differences.