NITRIC-OXIDE PRODUCTION AND MYCOBACTERIAL GROWTH-INHIBITION BY MURINEALVEOLAR MACROPHAGES - THE SEQUENCE OF RIFN-GAMMA STIMULATION AND MYCOBACTERIUM-BOVIS BCG INFECTION DETERMINES MACROPHAGE ACTIVATION

Authors
HANANO R KAUFMANN SHE
Citation
R. Hanano et She. Kaufmann, NITRIC-OXIDE PRODUCTION AND MYCOBACTERIAL GROWTH-INHIBITION BY MURINEALVEOLAR MACROPHAGES - THE SEQUENCE OF RIFN-GAMMA STIMULATION AND MYCOBACTERIUM-BOVIS BCG INFECTION DETERMINES MACROPHAGE ACTIVATION, Immunology letters, 45(1-2), 1995, pp. 23-27
Citations number
20
Categorie Soggetti
Immunology
Journal title
Immunology letters → ACNP
ISSN journal
01652478
Volume
45
Issue
1-2
Year of publication
1995
Pages
23 - 27
Database
ISI
SICI code
0165-2478(1995)45:1-2<23:NPAMGB>2.0.ZU;2-O
Abstract
Prestimulation with recombinant-interferon-gamma (rIFN-gamma) followed by Mycobacterium bovis BCG infection induced high nitric oxide produc tion and potent mycobacterial growth inhibition in murine alveolar mac rophages. Reversal of the sequence of treatments caused opposite effec ts, suggesting that a sequential 2-step process comprising first rIFN- gamma stimulation and second mycobacterial infection is operative in t he activation of alveolar macrophages.