SYNTHESIS OF NOVEL BORON-CONTAINING POLYAMINES - AGENTS FOR DNA TARGETING IN NEUTRON-CAPTURE THERAPY

Authors
HARIHARAN JR WYZLIC IM SOLOWAY AH
Citation
Jr. Hariharan et al., SYNTHESIS OF NOVEL BORON-CONTAINING POLYAMINES - AGENTS FOR DNA TARGETING IN NEUTRON-CAPTURE THERAPY, Polyhedron, 14(6), 1995, pp. 823-825
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear",Crystallography
Journal title
Polyhedron → ACNP
ISSN journal
02775387
Volume
14
Issue
6
Year of publication
1995
Pages
823 - 825
Database
ISI
SICI code
0277-5387(1995)14:6<823:SONBP->2.0.ZU;2-I
Abstract
A new class of carriers for Neutron Capture Therapy, boronated polyami nes, are presented that may possess a high affinity for DNA and rapid/ specific uptake in brain tumors by comparison with adjacent normal bra in. Two first boron-containing polyamines such as 1,8-diamino-4-(4-o-c arboranylbutyl)-4-azaoctane and 1,8-diamino-4-(3-o-carboranylpropyl)-4 -azaoctane were synthesized via silylation-alkylation reaction of bis- Boc-protected spermidine with either carboranyl iodides or tosylates.