Jr. Hariharan et al., SYNTHESIS OF NOVEL BORON-CONTAINING POLYAMINES - AGENTS FOR DNA TARGETING IN NEUTRON-CAPTURE THERAPY, Polyhedron, 14(6), 1995, pp. 823-825
A new class of carriers for Neutron Capture Therapy, boronated polyami
nes, are presented that may possess a high affinity for DNA and rapid/
specific uptake in brain tumors by comparison with adjacent normal bra
in. Two first boron-containing polyamines such as 1,8-diamino-4-(4-o-c
arboranylbutyl)-4-azaoctane and 1,8-diamino-4-(3-o-carboranylpropyl)-4
-azaoctane were synthesized via silylation-alkylation reaction of bis-
Boc-protected spermidine with either carboranyl iodides or tosylates.