3,5-DICHLORO-4-PYRIDINECARBONITRILE AS A KEY REAGENT IN A SYNTHESIS OF COPPER-CONTAINING AMINE OXIDASE-INHIBITORS

Authors
BERTINI V LUCCHESINI F POCCI M DEMUNNO A
Citation
V. Bertini et al., 3,5-DICHLORO-4-PYRIDINECARBONITRILE AS A KEY REAGENT IN A SYNTHESIS OF COPPER-CONTAINING AMINE OXIDASE-INHIBITORS, Heterocycles, 41(4), 1995, pp. 675-688
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
41
Issue
4
Year of publication
1995
Pages
675 - 688
Database
ISI
SICI code
0385-5414(1995)41:4<675:3AAKRI>2.0.ZU;2-I
Abstract
Various synthetic approaches to 3,4,5-trifunctionalized pyridine deriv atives useful as benzylamine oxidase inhibitors are extensively explor ed. Fully satisfactory preparations of the inhibitors 3,5-diethoxy-4-a minomethylpyridine (4), 3,5-bis(3-hydroxypropoxy)-4-aminomethylpyridin e (11), 3,5-bis(4-hydroxybutoxy)-4- aminomethylpyridine (12) and 3-eth oxy-5-phenylmethoxy-4-aminomethylpyridine (16), all in the form of dih ydrochloride salt, using 3,5-dichloro-4-pyridinecarbonitrile as key pr ecursor, are reported.