MODULATION OF WOUND-HEALING IN SWISS ALBINO MICE BY DIFFERENT DOSES OF GAMMA-RADIATION

Changes in wound healing were studied using artificial wounds created either by surgical excision of full thickness skin or partial skin thi ckness dermabrasion of dorsal skin of Swiss albino mice exposed to 2, 4 and 6 Gy of gamma radiation. There was a significant delay in the wo und healing process after exposure to 2 Gy when compared to the contro ls. With increasing doses of radiation wound healing lime was also del ayed However, the differences in wound healing limes between all three doses were not significant. The irradiation resulted in a dose-depend ent delay in the wound contraction and mean wound healing time. The ab rasion group was followed until complete epithelialization in the anim als exposed to 2, 4 and 6 Gy of gamma radiation. However, no significa nt difference was observed in the healing time with respect to non-irr adiated controls for all the exposure doses used in the present study.