SERUM ANTI-DEXTRAN ANTIBODIES IN IGA NEPHROPATHY

Citation
A. Kennel et al., SERUM ANTI-DEXTRAN ANTIBODIES IN IGA NEPHROPATHY, Clinical nephrology, 43(4), 1995, pp. 216-220
Citations number
28
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
03010430
Volume
43
Issue
4
Year of publication
1995
Pages
216 - 220
Database
ISI
SICI code
0301-0430(1995)43:4<216:SAAIIN>2.0.ZU;2-8
Abstract
Abnormally high humoral responses have been described in IgA nephropat hy (IgAN), towards antigens commonly involved in infectious events or food intolerance. Here we report a comparative analysis of humoral res ponses to a common environmental antigen, dextran B 512, present both in nonpathogenic microorganisms and normal diet. Dextran-specific IgG, IgA and IgM were assayed using an ELISA method in serum samples from 121 patients with IgAN, 40 controls and 32 patients with biopsy-proven renal diseases different from IgAN. Among the latter, 17 were transpl ant recipients. Anti-dextran IgG antibodies were found significantly ( p < 0.05) more frequently and at higher levels in IgAN patients than i n patients with other renal diseases. Anti-dextran IgA were at signifi cantly (p < 0.05) higher levels in IgAN patients than in controls or u ntransplanted NIgAN patients, However, similarly elevated levels of an ti-dextran IgA were found in IgAN patients and transplanted patients w ith other renal diseases. These data confirm that IgA and IgG response s towards common antigens are elevated in IgAN, possibly as a conseque nce of the pathogenesis of this disease rather than because of renal i mpairment. Moreover, since the same degree of dysregulation was noted in the control group of transplanted patients whose initial diagnosis was not IgAN, these data favour the hypothesis of a global dysregulati on of the IgA system in IgAN, yielding enhanced humoral immune respons es to possible pathogens and diet antigens.