GENETIC-POLYMORPHISM OF THE 6TH COMPONENT OF COMPLEMENT (C6) IN DOGS

Using agarose gel isoelectric focusing and immunoblotting with rabbit anti-rabbit C6, a genetic polymorphism was found in the sixth componen t of complement (C6) in 18 Asian native breeds or populations and thre e European breeds of dog. The C6 locus was highly polymorphic. The phe notype distribution data indicated that dog C6 phenotypes were control led by seven codominant alleles, C6(A), C6(B), C6(C), C6(D), C6(E), C6 (F) and C6(G), at a single autosomal locus. Breed differences were obs erved among the gene frequencies, especially between Asian and Europea n breeds. Two gene flows from the adjacent areas into Japanese native dogs were postulated.