YEAST MULTIDRUG-RESISTANCE - THE PDR NETWORK

This minireview describes a network of genes involved in multiple drug resistance of the yeast S. cer cerevisiae. The transcription regulato rs, PDR1, PDR3, PDR7, and PDR9 control the expression of the gene PDR5 , encoding a membrane protein of the ATP-binding-cassette superfamily and functioning as a drug extrusion pump. Next to PDR5, several other target genes, encoding membrane pumps of the ABC type, such as SNQ2, S TE6, PDR10, PDR11, YOR1, but also other membrane-associated (such as G AS1, D4405) or soluble proteins (such as G3PD), involved or not in mul tidrug resistance, are found to be controlled by PDR1. On another side , the PDR3 regulator participates with its homolog PDR1 to co- and aut o-regulation circuits of yeast multidrug resistance.