A NEW SYNTHESIS OF 2-SUBSTITUTED DL-TRYPTOPHAN DERIVATIVES

Authors
BALSAMINI C DIAMANTINI G DURANTI A SPADONI G TONTINI A
Citation
C. Balsamini et al., A NEW SYNTHESIS OF 2-SUBSTITUTED DL-TRYPTOPHAN DERIVATIVES, Synthesis, (4), 1995, pp. 370-372
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
4
Year of publication
1995
Pages
370 - 372
Database
ISI
SICI code
0039-7881(1995):4<370:ANSO2D>2.0.ZU;2-E
Abstract
Methyl 2-substituted N-(diphenylmethylene)-DL-tryptophanates were prep ared by means of Lewis acid catalysed Michael-type addition of methyl N-(diphenylmethylene)dehydroalaninate to suitable 2-substituted indole s. Hydrolysis of these tryptophan derivatives affords the correspondin g amino acids. Examples of selective deprotection of either the amino or carboxylic group are reported.