APOPTOSIS INDUCED BY HIGH-LET AND LOW-LET RADIATIONS

Authors
HENDRY JH POTTEN CS MERRITT A
Citation
Jh. Hendry et al., APOPTOSIS INDUCED BY HIGH-LET AND LOW-LET RADIATIONS, Radiation and environmental biophysics, 34(1), 1995, pp. 59-62
Citations number
20
Categorie Soggetti
Biophysics,"Radiology,Nuclear Medicine & Medical Imaging","Environmental Sciences
Journal title
Radiation and environmental biophysics → ACNP
ISSN journal
0301634X
Volume
34
Issue
1
Year of publication
1995
Pages
59 - 62
Database
ISI
SICI code
0301-634X(1995)34:1<59:AIBHAL>2.0.ZU;2-Q
Abstract
Cell death after irradiation occurs by apoptosis in certain cell popul ations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in i ntestinal crypts) for neutrons with energies of 14 MeV and up to 600 M eV. It is thought that p53 plays a role in the phenomenon, as radiatio n-induced apoptosis is not observed in p53-null animals.