NOVEL ANTITHROMBOTIC THERAPEUTICS TARGETED AGAINST PLATELET GLYCOPROTEIN IIB IIIA/

Authors
Citation
S. Coutre et L. Leung, NOVEL ANTITHROMBOTIC THERAPEUTICS TARGETED AGAINST PLATELET GLYCOPROTEIN IIB IIIA/, Annual review of medicine, 46, 1995, pp. 257-265
Citations number
31
Categorie Soggetti
Medicine, General & Internal
Journal title
ISSN journal
00664219
Volume
46
Year of publication
1995
Pages
257 - 265
Database
ISI
SICI code
0066-4219(1995)46:<257:NATTAP>2.0.ZU;2-T
Abstract
Platelet aggregation is one of the best understood examples of adhesiv e cell-cell interactions. The platelet glycoprotein IIb/IIIa membrane receptor plays a pivotal role in platelet aggregation through its bind ing of fibrinogen. it is intimately involved in the pathogenesis of pl atelet-rich arterial thromboses. Th, IIb/IIIa receptor is an important target for recently described novel antiplatelet therapeutics. The de velopment and clinical evaluation of this class of antiplatelet therap eutics are reviewed in this article.