Negative initial cervictomoy for primary hyperparathyroidism can be du
e to one of two reasons: first, one gland has not been found: it was a
n missing adenoma on an ectopic gland. Secondly, four normal glands we
re found: a missing adenoma arising in a supernumerary and ectopic gla
nd. Successful parathyroid surgery depends the on surgeon's experience
, his knowledge of parathyroid gland embryology, and his perseverance
to find the pathologic gland. After an unsuccessful cervicotomy, the n
ecessity for reoperation must be discussed. Before reexploration, diag
nosis of hyperparathyroidism must be reviewed, the operative notes and
pathologic report of the previous operation must be studied, and loca
lization studies must be performed in order to define the cervical or
mediastinal surgical approach.