SYNTHESIS OF RETIFEROL RAD(1) AND RAD(2), THE LEAD REPRESENTATIVES OFA NEW CLASS OF DES-CD ANALOGS OF CHOLECALCIFEROL

Authors
KUTNER A ZHAO H FITAK H WILSON SR
Citation
A. Kutner et al., SYNTHESIS OF RETIFEROL RAD(1) AND RAD(2), THE LEAD REPRESENTATIVES OFA NEW CLASS OF DES-CD ANALOGS OF CHOLECALCIFEROL, Bioorganic chemistry, 23(1), 1995, pp. 22-32
Citations number
40
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology
Journal title
Bioorganic chemistry → ACNP
ISSN journal
00452068
Volume
23
Issue
1
Year of publication
1995
Pages
22 - 32
Database
ISI
SICI code
0045-2068(1995)23:1<22:SORRAR>2.0.ZU;2-J
Abstract
The design and total convergent synthesis are described for the leadin g representatives of the new class of analogs of cholecalciferol with the CD-ring system replaced with a two-carbon aliphatic spacer. The le ading representatives of C-21 retiferols (RAD(1) and RAD(2)) were obta ined from a ring fragment derived from vitamin D and a chain fragment obtained from S-(-)-beta-citronellol. (C) 1995 Academic Press, Inc.