MORPHOLOGIC CHANGES OF DOXORUBICIN-SENSITIVE AND RESISTANT LOVO CELLSTREATED IN-VITRO BY CALCIUM CHANNELS BLOCKERS

A morphological analysis by scanning electron microscopy (SEM) of the effect of two Ca++ channel blockers (verapamil and dilazep) on LoVo S (doxorubicin sensitive) and LoVo R (doxorubicin resistant) plated toge ther with 3T3 in order to cause an experimental ground of metastasis w as performed. Ca++ channel blockers have been previously tested alone and combined with doxorubicin. The increasing effect on the sensitivit y of inherently antiblastic drug resistance and their possible role as antimetastatic agent according to the experiments of Tsuruo et al (Ca ncer Chemother Pharmacol 14: 30-33, 1985) is reported.