OPTIMIZATION OF PROTOCOL FOR AUTOMATIC SO LID-PHASE PEPTIDE-SYNTHESISUSING VARIABLE VOLUME FLOW-REACTOR

Authors
MOSHNIKOV SA MUSTAEVA LG DANILOV AV SUHOV IE BARU MB
Citation
Sa. Moshnikov et al., OPTIMIZATION OF PROTOCOL FOR AUTOMATIC SO LID-PHASE PEPTIDE-SYNTHESISUSING VARIABLE VOLUME FLOW-REACTOR, Bioorganiceskaa himia, 21(3), 1995, pp. 179-187
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
21
Issue
3
Year of publication
1995
Pages
179 - 187
Database
ISI
SICI code
0132-3423(1995)21:3<179:OOPFAS>2.0.ZU;2-B
Abstract
The protocol for solid phase peptide synthesis using automatic synthes izers MilliGen/Biosearch 9500 and 9600 with built-in variable volume-f low-reactors has been elaborated. The data of swellographic monitoring were used for optimization of process parameters. The peptides involv ing from 10 to 21 amino acid residues were synthesized using developed protocol. Significant economy of reagents and solvents has been demon strated for synthesis of good quality peptides.