INVESTIGATION OF MECHANISM OF INSECTICIDE AND ACARICIDE ACTION OF THIOORGANOPHOSPHORUS COMPOUNDS CONTAINING FRAGMENTS OF N-CARBALKOXYLATED AMINO-ACIDS

Toxicity and insecticide and acaricide activity of compounds (1) is si gnificantly dependent on the nature of amino acid (n = 1 or 2) and sub stituents in carbamate and amino acid ester groups (R and R(1)). Inves tigation of interaction of these compounds with mammalian carboxyester ases, and the appropriate ''oxones'' with choline esterases of mammal and arthropoda revealed that the lower toxicity and activity of beta-a lanine derivatives (n = 2) compared with glycine derivatives (n = 1) a re due to the more rapid hydrolysis by carboxylesterases (detoxication ). The low toxicity of dithiophosphonate with R = Me, R(1) = Bu(i), n = 1 and the high toxicity of its isomer with R = Bu(i), R(1) = Me, n = 1 are associated with the more rapid oxidativ cleavage of isobutyl gr oup in comparison with the other substituents, because detoxication oc curs by the cleavage of R(1) and activation - by that of R respectivel y.