CORRELATION-ANALYSIS OF REACTIVITY IN THE OXIDATION OF 3,5-DIMETHYL-2,6-DIARYL-4-PIPERIDONES BY PEROXOMONOSULFATE

Kinetics of oxidation of /di-p-chlorophenyl/di-p-nitrophenyl)-4-piperi dones by peroxomonosulphate in aqueous acetic acid medium have been st udied. The reactions are first order, both in the piperidone and in th e oxidant. Electron-withdrawing groups are found to accelerate the rat e of oxidation and the electron-releasing groups retard it. The Hammet t rho sigma relationship is used to correlate reactivity with structur e. The rates of oxidation show an excellent correlation with sigma deg rees values with a positive reaction constant rho. A linear isokinetic relationship substantiates the validity of linear free energy relatio nships. Correlation analysis effectively supports the proposed mechani sm.