DNA FRAGMENTATION INDICATIVE OF APOPTOSIS FOLLOWING UNILATERAL CEREBRAL HYPOXIA-ISCHEMIA IN THE NEONATAL RAT

Authors
HILL IE MACMANUS JP RASQUINHA I TUOR UI
Citation
Ie. Hill et al., DNA FRAGMENTATION INDICATIVE OF APOPTOSIS FOLLOWING UNILATERAL CEREBRAL HYPOXIA-ISCHEMIA IN THE NEONATAL RAT, Brain research, 676(2), 1995, pp. 398-403
Citations number
31
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
676
Issue
2
Year of publication
1995
Pages
398 - 403
Database
ISI
SICI code
0006-8993(1995)676:2<398:DFIOAF>2.0.ZU;2-L
Abstract
DNA extracted from regional brain samples of hypoxic/ischemic neonatal rats showed internucleosomal cleavage indicative of apoptosis. Cells containing cleaved DNA were identified by in situ labelling in the cor tex, hippocampus, striatum and thalamus of the ipsilateral hemisphere. When the effects of increasing the length of the hypoxia were examine d, increases were seen in the amount of internucleosomally cleaved DNA and in the number of labelled cells.