REGION-RELATED FOS EXPRESSION IN HYPOTHALAMIC DOPAMINERGIC-NEURONS OFRATS BY INTRAPERITONEAL ADMINISTRATION OF AN ENDOGENOUS SATIETY SUBSTANCE, 2-BUTEN-4-OLIDE

An effect of 2-buten-4-olide (2-B40), an endogenous satiety substance, on hypothalamic dopamine neurons of rats was studied by double-label immunohistochemistry for c-Fos and tyrosine hydroxylase (TH). Intraper itoneal administration of 2-B40 induced Fos-like immunoreactivity in T H-immunoreactive neurons in the periventricular area and paraventricul ar nucleus but not in the arcuate nucleus. Thus, the present results s uggest that tuberohypophysial dopamine neurons are regulated under the influence of endogenous 2-B40.