OSTEOPOROSIS IN SEVERE CONGENITAL NEUTROPENIA TREATED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR

Authors
BISHOP NJ WILLIAMS DM COMPSTON JC STIRLING DM PRENTICE A
Citation
Nj. Bishop et al., OSTEOPOROSIS IN SEVERE CONGENITAL NEUTROPENIA TREATED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR, British Journal of Haematology, 89(4), 1995, pp. 927-928
Citations number
8
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
89
Issue
4
Year of publication
1995
Pages
927 - 928
Database
ISI
SICI code
0007-1048(1995)89:4<927:OISCNT>2.0.ZU;2-S
Abstract
Recombinant human granulocyte colony-stimulating factor (G-CSF) has su bstantially improved life expectancy for children with severe congenit al neutropenia (SCN). Severe osteoporosis, reported in this population , may relate to the disease process, or be a therapeutic side-effect. This report details bone loss, quantitated absorptiometrically and his tomorphometrically, in a child with SCN and vertebral collapse, and th e positive response to anabolic steroid and bisphosphonate therapy.