Bkj. Wagner et al., EFFECTS OF INTRAVENOUS FAMOTIDINE ON GASTRIC-ACID SECRETION IN PATIENTS UNDERGOING CARDIAC-SURGERY, The Annals of pharmacotherapy, 29(4), 1995, pp. 349-353
OBJECTIVE: To determine the effects of cardiopulmonary bypass and famo
tidine on gastric acid secretion in adults undergoing cardiac surgery.
DESIGN: Prospective, randomized, double-blind, placebo-controlled stu
dy. SETTING: University teaching hospital. PARTICIPANTS: Eighteen pati
ents undergoing elective cardiac surgery with cardiopulmonary bypass.
MAIN OUTCOME MEASURES: Famotidine 20 mg or NaCl 0.9% placebo was admin
istered intravenously following induction of anesthesia and placement
of a nasogastric pH probe. A second dose was given 12 hours after surg
ery in the intensive care unit. Gastric pH was measured continuously a
nd gastric volume was measured every 4 hours for up to 24 hours after
cardiopulmonary bypass. RESULTS: Following famotidine administration,
pH increased by 43% within 45 minutes and remained above 5.5 throughou
t the study period (p < 0.05 vs placebo and baseline). The gastric pH
did not increase, but remained above 4.0 in most patients in the place
bo group for up to 12 hours after cardiopulmonary bypass. Gastric volu
mes were on average 24% lower in the famotidine group (p > 0.05). CONC
LUSIONS: Gastric acid secretion is decreased during and for 12 hours a
fter cardiopulmonary bypass. Perioperative administration of famotidin
e suppresses gastric secretion in cardiac surgery patients.