TRANSPLACENTAL PASSAGE AND MILK EXCRETION OF IOBITRIDOL

RATIONALE AND OBJECTIVES. Iobitridol, a new nonionic, low-osmolality u rographic and angiographic contrast medium, is a marker of extracellul ar fluid. Excretion of iobitridol in goat's milk and transplacental pa ssage in the gestating rabbit were evaluated compared with iohexol. ME THODS. Both products were determined in biologic samples by two analyt ic methods: ultraviolet spectrometry (milk) and high-pressure liquid c hromatography (maternal and fetal blood and amniotic fluid). RESULTS. Excretion in the milk represents 0.7% of the administered dose for iob itridol and 1.6% for iohexol. Transplacental passage is nonexistent. I obitridol and iohexol behave in a similar manner. CONCLUSIONS. These p reclinical results allow more effective prediction of the safety of io bitridol in pregnant or lactating women. However, precautions for use must be respected in the absence of specific studies in this populatio n group.