PAPOVA VIRUSES AND RECURRENT LARYNGEAL PAPILLOMATOSIS

The pathogenesis of larynx papillomas has been a challenge of medical science for a long time. Both clinical observations and electronmicros copical examinations have made it possible to establish the viral orig in. Final evidence, however, has been achieved only by complicated imm unhistochemical investigations. The Papova viruses-types 6 and/or 11-c an be detected with in situ hybrizidation polymerase chain reaction am plification. HPV can be positivity demonstrated not only from visible papillomas but-in significant percentage-in neighboring healthy-lookin g mucous membranes. It may reveal the inadequacies of removal of lesio ns and the need for adjuvant therapy. To make treatment more effective we have developed a therapeutic regimen that combines CO2 laser micro surgery with immunostimulants.