NUCLEAR-RELAXATION STUDIES IN LIGAND-MACROMOLECULE AFFINITY INDEX DETERMINATIONS

Authors
ROSSI C DONATI A BONECHI C CORBINI G RAPPUOLI R DREASSI E CORTI P
Citation
C. Rossi et al., NUCLEAR-RELAXATION STUDIES IN LIGAND-MACROMOLECULE AFFINITY INDEX DETERMINATIONS, Chemical physics letters, 264(1-2), 1997, pp. 205-209
Citations number
16
Categorie Soggetti
Physics, Atomic, Molecular & Chemical
Journal title
Chemical physics letters → ACNP
ISSN journal
00092614
Volume
264
Issue
1-2
Year of publication
1997
Pages
205 - 209
Database
ISI
SICI code
0009-2614(1997)264:1-2<205:NSILAI>2.0.ZU;2-T
Abstract
An 'affinity index', representing the global affinity between a ligand and a biomacromolecular receptor, is proposed. It is determined as th e slope of the linear relations between Delta R(1)(SE) and the recepto r concentration and has the advantage of providing a measure of the li gand-biomacromolecule global affinity which is independent of the numb er of interaction sites. The method was applied to the calculation of the lamotrigine-albumin affinity index.