Appetite suppressants, including aminorex and fenfluramine, have been
associated with pulmonary hypertension ever since the well-known outbr
eak of primary pulmonary hypertension in Europe after treatment with a
minorex, The usage of a new anorectic agent, dexfenfluramine, has rece
ntly increased dramatically in developed countries. We report 2 new ca
ses of lethal pulmonary hypertension associated with the use of dexfen
fluramine.