INHIBITION OF ANGIOGENESIS AND GROWTH OF HUMAN NONMALIGNANT AND MALIGNANT MENINGIOMAS BY TNP-470

Meningiomas are relatively common (22%) vascular brain tumors. 3-11% o f meningiomas are malignant, and defy currently available therapy. Inh ibition of neovascularization is one potential strategy for treating t hese hypervascular tumors. Inhibition of tumor-induced angiogenesis by TNP-470 (previously termed AGM-1470), a synthetic analogue of fumagil lin, was tested on the growth of human non-malignant and malignant men ingiomas in nude mice. TNP-470 significantly inhibited tumor neovascul arization and tumor growth of both non-malignant and malignant meningi omas. TNP-470 is now in human trial and should be tested for efficacy in treating malignant or recurrent aggressive meningiomas.