CLINICAL-APPLICATION OF F-18 FUDR IN GLIOMA PATIENTS - PET STUDY OF NUCLEIC-ACID METABOLISM

Authors
KAMEYAMA M ISHIWATA K TSURUMI Y ITOH J SATO K KATAKURA R YOSHIMOTO T HATAZAWA J ITO M IDO T
Citation
M. Kameyama et al., CLINICAL-APPLICATION OF F-18 FUDR IN GLIOMA PATIENTS - PET STUDY OF NUCLEIC-ACID METABOLISM, Journal of neuro-oncology, 23(1), 1995, pp. 53-61
Citations number
42
Categorie Soggetti
Neurosciences,Oncology
Journal title
Journal of neuro-oncology → ACNP
ISSN journal
0167594X
Volume
23
Issue
1
Year of publication
1995
Pages
53 - 61
Database
ISI
SICI code
0167-594X(1995)23:1<53:COFFIG>2.0.ZU;2-N
Abstract
Positron emission tomography was used to investigate the metabolism of nucleic acids by F-18-fluoro-2'-deoxyuridine (F-18-FUdR) in 22 patien ts with gliomas. Sixteen cases of high grade glioma clearly demonstrat ed a region of high activity with a differential absorption rate (DAR) of 0.64 +/- 0.34. Six cases of low grade glioma failed to reveal a po sitive image of the tumor and the DAR in tumor was 0.21 +/- 0.042 (p < 0.01). This PET-F-18-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.