SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 5-COORDINATE PLATINUM(II) COMPLEXES INCLUDING ORGANOTIN FRAGMENTS

Authors
CARPINELLI P BARTOLUCCI S RUFFO F
Citation
P. Carpinelli et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 5-COORDINATE PLATINUM(II) COMPLEXES INCLUDING ORGANOTIN FRAGMENTS, Anti-cancer drug design, 10(1), 1995, pp. 43-49
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Oncology,Biology
Journal title
Anti-cancer drug design → ACNP
ISSN journal
02669536
Volume
10
Issue
1
Year of publication
1995
Pages
43 - 49
Database
ISI
SICI code
0266-9536(1995)10:1<43:SABO5P>2.0.ZU;2-4
Abstract
The synthesis and characterization of two five-coordinate platinum(II) complexes of general formula [PtCl(SnMe(n)Cl3-n)(2,9-Me2-1,l0-phenant hroline) (diethylfumarate)] (n = 1, 2) are described. The bimetallic s pecies were tested on the neuroblastoma cell line SK-N-BE and a consid erable inhibition of cellular proliferation was detected; the bimetall ic species were also able to induce neuronal differentiation, as did r etinoic acid, a well-known neuroblastoma differentiating agent.