The diffusion behaviour of a Brownian particle in a crystal with rando
mly distributed topological defects is analyzed by means of the contin
uum theory of defects combined with the theory of diffusion on manifol
ds. A path-integral representation of the diffusion process is used fo
r the calculation of cumulants of the particle position averaged over
a defect ensemble. For a random distribution of disclinations the prob
lem of Brownian motion reduces to a known random-drift problem. Depend
ing on the properties of the disclination ensemble, this yields variou
s types of subdiffusional behaviour. In a random array of parallel scr
ew dislocations one finds a normal, but anisotropic, diffusion behavio
ur of the mean-square displacement. Moreover, the process turns out to
be non-Gaussian, and reveals long-time tails in the higher-order cumu
lants.