THE EXPRESSION OF THE GENE CODING FOR PARATHYROID HORMONE-RELATED PROTEIN (PTHRP) DURING TOOTH DEVELOPMENT IN THE RAT

Citation
F. Beck et al., THE EXPRESSION OF THE GENE CODING FOR PARATHYROID HORMONE-RELATED PROTEIN (PTHRP) DURING TOOTH DEVELOPMENT IN THE RAT, Cell and tissue research, 280(2), 1995, pp. 283-290
Citations number
66
Categorie Soggetti
Cell Biology
Journal title
ISSN journal
0302766X
Volume
280
Issue
2
Year of publication
1995
Pages
283 - 290
Database
ISI
SICI code
0302-766X(1995)280:2<283:TEOTGC>2.0.ZU;2-4
Abstract
By means of in situ hybridisation studies, it is shown that parathyroi d hormone-related protein (PTHrP) mRNA is strongly expressed in the de veloping enamel organs of rat teeth. In particular, the cervical loop hybridises strongly with the PTHrP probe and expression is maintained at this site throughout life in the permanently erupting incisor teeth . In mature molar teeth, expression is downregulated to low levels and confined to the epithelial cell rests of Malassez and/or cementoblast s which may derive from these. The gene is also expressed at low level s in the tissue overlying the erupting molars and, thereafter, in the junctional epithelia and connective tissue cells of the epithelial att achment on all tooth surfaces. The premise that PTHrP may undergo post -translational processing and that the resultant products could act in different ways raises the possibility of its exerting multiple paracr ine actions during tooth development. These could include the control of cell division and local vascular dilation during development.