GLYCINERGIC INHIBITION OF SPONTANEOUSLY ACTIVE GUINEA-PIG MEDIAL VESTIBULAR NUCLEUS NEURONS IN-VITRO

Authors
LAPEYRE PNM DEWAELE C
Citation
Pnm. Lapeyre et C. Dewaele, GLYCINERGIC INHIBITION OF SPONTANEOUSLY ACTIVE GUINEA-PIG MEDIAL VESTIBULAR NUCLEUS NEURONS IN-VITRO, Neuroscience letters, 188(3), 1995, pp. 155-158
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
188
Issue
3
Year of publication
1995
Pages
155 - 158
Database
ISI
SICI code
0304-3940(1995)188:3<155:GIOSAG>2.0.ZU;2-M
Abstract
Effects of glycine on the spontaneous activity of medial vestibular nu cleus (MVN) neurons recorded extracellularly from guinea-pig brainstem slices were investigated. Glycine produced a dose-dependent decrease in the resting discharge rate of all MVN neurons tested, with a mean E C(50) Of 3.9 x 10(-4) M. The inhibitory effect of glycine was reversib ly blocked by strychnine and persisted in a low calcium/high magnesium -containing saline solution. These findings suggest the existence of a direct strychnine-sensitive inhibitory Effect of glycine on guinea-pi g MVN neurons.