Plasma homovanillic acid concentration was assessed in 60 young schizo
phrenic patients, with and without first-degree relatives with schizop
hrenia, before treatment, and 3 days after starting haloperidol treatm
ent, The baseline concentration of homovanillic acid in plasma was no
different in the two groups before treatment; it was, however, signifi
cantly higher in the patients with relatives than in those without rel
atives diagnosed of schizophrenia after 3 days of haloperidol treatmen
t. (C) 1995 Wiley-Liss, Inc.