We report the clinical and scanning electron microscopic findings in a
n older adult patient with unilateral posterior keratoconus. Clinicall
y, the cornea showed typical posterior concavity with focal underlying
anterior ectasia and an epithelial iron ring. Scanning electron micro
scopy of the cornea removed at penetrating keratoplasty revealed a per
icentral posterior concavity. The endothelial layer was intact, with m
oderate endothelial cell pleomorphism. There were no excrescences of D
escemet's membrane or endothelial tags. The lack of discrete irregular
ities on the posterior corneal surface in this case is different from
previous descriptions of the pathological appearance of posterior kera
toconus, which have been used to support a relationship of this condit
ion to central corneal mesenchymal dysgenesis. This is the first repor
t of scanning electron microscopic findings in posterior keratoconus.