The effects of early supplementary feeding on cognition are investigat
ed using data collected during two periods in four Guatemalan villages
, The first was the Institute of Nutrition of Central America and Pana
ma (INCAP) longitudinal study from 1969 to 1977 and the second was a c
ross-sectional follow-up of former participants carried out in 1988-19
89. The principal objective of these studies was to assess the differe
ntial effect of two dietary supplements, Atole containing 163 kca1/682
kJ and 11.5 g protein per cup or 180 mL and Fresco containing 59 kcal
/247 kJ and 9 g protein per cup, that were given to mothers, infants a
nd young children, Performance was assessed on a battery of psychoeduc
ational and information processing tests that were administered during
adolescence. Consistent differences between groups were observed on p
sychoeducational tests, Subjects receiving Atole scored significantly
higher on tests of knowledge, numeracy, reading and vocabulary than th
ose given Fresco, Atole ingestion also was associated with faster reac
tion time in information processing tasks, In addition, there were sig
nificant interactions between type of dietary supplement and socioecon
omic status (SES) of subjects, In Atole villages, there were no differ
ences in performance between subjects in the lowest and highest SES ca
tegories. On the other hand, performance in Fresco villages was best i
n the highest compared with the lowest SES group. After close scrutiny
of alternative hypotheses, it is concluded that dietary changes produ
ced by supplementation provide the strongest explanation for the test
performance differences observed in the follow-up between subjects exp
osed to Atole and those exposed to Fresco supplementation.