AN EXPEDITIOUS SYNTHESIS OF STRUCTURAL ANALOGS OF THE MARINE CYTOTOXIC AGENTS GROSSULARINES-1 AND GROSSULARINES-2

Authors
ACHAB S GUYOT M POTIER P
Citation
S. Achab et al., AN EXPEDITIOUS SYNTHESIS OF STRUCTURAL ANALOGS OF THE MARINE CYTOTOXIC AGENTS GROSSULARINES-1 AND GROSSULARINES-2, Tetrahedron letters, 36(15), 1995, pp. 2615-2618
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
15
Year of publication
1995
Pages
2615 - 2618
Database
ISI
SICI code
0040-4039(1995)36:15<2615:AESOSA>2.0.ZU;2-C
Abstract
A short access to 2-carbethoxy-3-(5-imidazolyl)indoles (13, 14, 16), f eaturing Pd-catalyzed cross coupling between 3-iodoindoles (10-12) and imidazolostannane (9) has been developed. These derivatives when subj ected to tandem modified Curtius rearrangement-intramolecular electroc yclization led to the pyridones (19-23) which are key intermediates in the synthesis of the analogs (31), (33) and (36) of the naturally occ urring cytotoxic alpha-carbolines grossularines-1 and -2 (1,2).