NEW CYTOTOXIC POLYOXYGENATED STEROIDS FROM THE SPONGE DYSIDEA INCRUSTANS

Authors
CASAPULLO A MINALE L ZOLLO F ROUSSAKIS C VERBIST JF
Citation
A. Casapullo et al., NEW CYTOTOXIC POLYOXYGENATED STEROIDS FROM THE SPONGE DYSIDEA INCRUSTANS, Tetrahedron letters, 36(15), 1995, pp. 2669-2672
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
15
Year of publication
1995
Pages
2669 - 2672
Database
ISI
SICI code
0040-4039(1995)36:15<2669:NCPSFT>2.0.ZU;2-7
Abstract
Two novel polyoxygenated steroids, incrustasterol A (1) and B (2), hav e been isolated from the marine sponge Dysidea incrustans, collected i n the Mediterranean sea along the coasts of Tunisia. The structures, w hich include a rare Delta(8(9)), 11-keto functionality along with othe r oxygenated functions on the rings A and B, were determined by interp retation of spectral data. These steroids were cytotoxic against human non-small-cell lung, renal and melanoma carcinoma cell lines.