ATOMIC-EMISSION SPECTROMETRIC DETERMINATION OF ANTAZOLINE, HYDRALAZINE AND AMILORIDE HYDROCHLORIDES, AND QUININE SULFATE BASED ON FORMATIONOF ION ASSOCIATES WITH MANGANESE THIOCYANATE
Af. Shoukry et al., ATOMIC-EMISSION SPECTROMETRIC DETERMINATION OF ANTAZOLINE, HYDRALAZINE AND AMILORIDE HYDROCHLORIDES, AND QUININE SULFATE BASED ON FORMATIONOF ION ASSOCIATES WITH MANGANESE THIOCYANATE, Analyst, 120(4), 1995, pp. 1211-1213
Ion associate complexes of the hydrochlorides of antazoline (1), hydra
lazine (2) and amiloride (3), and quinine sulfate (4) with [Mn(SCN)(4)
](2-) were precipitated and their solubilities were studied as a funct
ion of pH, ionic strength and temperature. The optimum conditions for
the complete precipitation of the ion associate were, thus, elucidated
. An accurate and precise method using atomic emission spectrometry fo
r the determination of the investigated drugs in pure solutions and in
pharmaceutical preparations is reported. The drugs can be determined
by this method in the ranges 0.3-3.0, 0.19-1.96, 0.3-3.0 and 0.78-7.82
mg per 25 ml solutions of (1), (2), (3) and (4), respectively.