FREQUENT LOSS OF CHROMOSOME ARMS 8P AND 13Q IN COLLECTING DUCT CARCINOMA (CDC) OF THE KIDNEY

Collecting duct carcinoma (CDC) is a malignant renal neoplasm that is believed to arise from the epithelium of the ducts of Bellini in the d istal nephron, These tumors are clinically aggressive and more often o ccur in a younger population than is typical of the more common clear cell renal carcinoma (RCC). Using highly informative polymorphic micro satellite markers on chromosome arms 3p, 5q, 6q, 8p, 9p, 9q, 11p, 13q, 17p, and 18q, we analyzed DNA from nonmalignant and tumor tissue in 6 cases of CDC. We found no evidence of 3p loss of heterozygosity (LOH) in these renal rumors by using multiple markers, a finding that disti nguishes CDC from RCC in which 3p LOH has frequently been observed, We found LOH bf 8p in 50% of the tumors examined; in addition, we observ ed LOH of 13q in 50% of the rumors studied, Interestingly, 8p LOH may be associated with high stage and poor clinical prognosis. These data suggest that the molecular events responsible for the development of C DC differ from those associated with the origin of RCC, and thar. tumo r suppressor genes on 8p and 13q may be involved in the pathogenesis o f CDC. (C) 1995 Wiley-Liss, Inc.