Hc. Li et E. Khor, A COLLAGEN-POLYPYRROLE HYBRID - INFLUENCE OF 3-BUTANESULFONATE SUBSTITUTION, Macromolecular chemistry and physics, 196(6), 1995, pp. 1801-1812
Hybrid biomaterials derived from a water-soluble derivative of polypyr
role, poly[sodium 4-(3-pyrrolyl)butanesulfonate], and soluble collagen
have been synthesized by chemical polymerization of the 4-(3-pyrrolyl
)butanesulfonate monomer in a collagen solution. Interaction between t
he two polymers was evident in the formation of a precipitated black p
olymer-collagen gel obtained for a monomer concentration of 0,01 mol/L
. The collagen content in the gel was determined to be around 38 wt-%.
When the monomer concentration was increased five-fold, the product w
as a dispersed precipitate that was polymer rich with a corresponding
decrease in collagen (11 wt-%) content. Fourier transform infrared spe
ctroscopy and thermal analysis of the hybrids provide signs of interac
tion between the sulfonic acid group on the substituted pyrrole and si
de groups of amino acids in collagen. The electrical conductivities of
these hybrid biomaterials were found to be in the 10(-2) S cm(-1) ran
ge.