ATYPICAL DUCTAL HYPERPLASIA DIAGNOSED AT STEREOTAXIC CORE BIOPSY OF BREAST-LESIONS - AN INDICATION FOR SURGICAL BIOPSY

OBJECTIVE, The purpose of this study was to evaluate the prevalence of carcinoma found at surgical biopsy of lesions identified as atypical ductal hyperplasia by stereotaxic core breast biopsy, SUBJECTS AND MET HODS. Stereotaxic core biopsies of 264 mammographically evident lesion s were done with the patients lying prone on a dedicated stereotaxic t able, with an automated gun and a 14-gauge needle, Atypical ductal hyp erplasia was identified in 25 (9%) of 264 lesions, including four (3%) of 159 masses and 21 (20%) of 105 lesions evident as calcifications. Surgical biopsy was recommended in all 25 of these cases and was perfo rmed in 21, Results of stereotaxic core biopsy and surgery in these 21 cases were reviewed and correlated, RESULTS. Of 21 cases identified a s atypical ductal hyperplasia at stereotaxic core biopsy that were sub sequently evaluated with surgical biopsy, histopathologic analysis of the surgical specimen yielded benign histologic findings without atypi a in four (19%), atypical ductal hyperplasia in six (29%), and carcino ma in 11 (52%), Of the 11 carcinomas, histologic findings showed ducta l carcinoma in situ in eight (73%) and invasive ductal carcinoma in th ree (27%), CONCLUSION, The finding of atypical ductal hyperplasia at s tereotaxic core breast biopsy is an indication for surgical biopsy bec ause of the high prevalence of ductal carcinoma in these lesions.