CHROMOSOMAL MAPPING OF THE GENES FOR THE HUMAN CELL-CYCLE PROTEINS CYCLIN-C (CCNC), CYCLIN-E (CCNE), P21 (CDKN1) AND KAP (CDKN3)

Many gene products associated with the cdk cell cycle kinases are thou ght to regulate the active kinase complex and thus regulate the transi tion points of the cell cycle. Genes encoding these proteins may poten tially function as oncogenes or tumor suppressor genes. We describe th e chromosomal mapping by FISH of the genes for several cdk-associated proteins including human CCNC (cyclin C) to 6q21, CCNE (cyclin E) to 1 9q12-->q13, CDKN1 (p21) to 6p21.2 and CDKN3 (KAP to 14q22). Some of th ese sites are near chromosomal translocations or LOH sites common to a variety of human tumors. The potential role for each of these genes i n neoplasia is discussed.