Sj. Hunt et Ss. Shin, SOLITARY RETICULOHISTIOCYTOMA IN PREGNANCY - IMMUNOHISTOCHEMICAL AND ULTRASTRUCTURAL-STUDY OF A CASE WITH UNUSUAL IMMUNOPHENOTYPE, Journal of cutaneous pathology, 22(2), 1995, pp. 177-181
A case of a solitary reticulohistiocytoma during pregnancy is reported
. The tumor arose on the right thigh of a 31-year-old woman during the
2nd month of gestation. Physical examination 6 months later revealed
a 9 x 6 mm yellowish white papule. A biopsy showed a dermal proliferat
ion of spindle to polygonal cells embedded in fibrous tissue with admi
red neutrophils, eosinophils, and lymphocytes. Immunohistochemistry wa
s positive for S-100, factor XIIIa, HLA-DR, KP-1, vimentin, and neuron
-specific enolase. Ultrastructurally, the cells showed abundant lipid,
lysozomes, and endoplasmic reticulum. No Birbeck granules could be id
entified. The results suggest an aberrant immunophenotype intermediate
between indeterminate cells and dermal dendritic cells. The relations
hip of these lineages to reticulohistiocytoma and other dermal prolife
rative disorders is reviewed.