PLATIN SALTS-INDUCED HEMOLYTIC-ANEMIA - CISPLATIN-INDUCED AND THE FIRST CASE OF CARBOPLATIN-INDUCED HEMOLYSIS

Anemia is a common side effect of cisplatin, especially after repeated infusions. The primary mechanism is a myelosuppression caused by cisp latin's interference with iron metabolism, resulting in a lower count of red cell precursors. Some authors report a hemolytic anemia similar to penicillin-induced anemia, in which hemolysis is caused by an anti globulin antibody directed against red cell membrane-bound cisplatin. The authors report two cases of cisplatin-induced anemia and suggest t hat the immune-complex hypothesis is responsible for hemolysis. The fi rst case of carboplatin-induced hemolysis is also reported. Mechanisms of hemolysis and clinical practice are discussed.