Ja. Pujol et al., IMPROVEMENT OF SCLEREDEMA ASSOCIATED WITH IGA MULTIPLE-MYELOMA AFTER CHEMOTHERAPY, Clinical and experimental dermatology, 20(2), 1995, pp. 149-152
The presence oi a monoclonal gammopathy in patients with chronic scler
edema is a recently described, unusual association of unknown signific
ance. There have been very occasional reports of multiple myeloma in s
uch patients. We now report a patient with long-standing scleredema wh
o developed an IgA-kappa multiple myeloma. Once chemotherapy for the m
yeloproliferative disorder was instituted, scleredema improved signifi
cantly, suggesting a pathogenetic link between the two conditions.