Cj. Cole et al., POSTOPERATIVE RADIATION OF FREE JEJUNAL AUTOGRAFTS IN PATIENTS WITH ADVANCED CANCER OF THE HEAD AND NECK, Cancer, 75(9), 1995, pp. 2356-2360
Background. Free jejunal autografts increasingly are being used to rep
air the pharynx after resections of head and neck carcinomas. Doses of
greater than 45 Gy are generally considered to be above the tolerance
of the small bowel, whereas the dose range for effective postoperativ
e radiotherapy of advanced head and neck cancers is between 57.6 Gy an
d 63 Gy. Between July 1988, and December, 1992, 29 patients at the M.
D. Anderson Cancer Center were treated with a combination of resection
of the advanced head and neck cancer, reconstruction with free jejuna
l autograft, and postoperative radiation. Planned reductions in postop
erative doses due to the presence of the jejunum within the field were
not made. This retrospective study analyzes the outcome of these pati
ents with attention to survival, local-regional control, and complicat
ions. Methods. Twenty-seven of the 29 study patients had squamous cell
carcinoma of the larynx or pharynx; 24 of these patients had Stage II
I or Stage IV disease. Two patients had recurrent papillary thyroid ca
rcinoma. The median number of days from surgery to the start of radiat
ion was 34. Radiation doses to the tumor bed ranged from 50 Gy to 72 G
y. The median doses to the tumor bed and the jejunal autograft were bo
th 63 Gy. Surviving patients were followed from 12 to 68 months (media
n, 20 months) from the time of their surgery. Results. The actuarial 2
-year survival rate was 51%. Nine patients had local or regional recur
rences above the clavicles. The 2-year local-regional control and free
dom from relapse rates were 71 and 50%, respectively. The most severe
complication during radiation was confluent mucositis in greater than
50% of the treated area, which developed in two patients. No patient d
eveloped a late complication related to the jejunal autograft. Conclus
ions. Postoperative radiation to free jejunal autografts used for phar
yngeal reconstruction can be delivered safely. Doses in this setting o
f 57.6 Gy to 63 Gy depending on the anticipated risk of recurrence bas
ed on clinical, surgical, and pathologic findings are recommended. The
presence of a free jejunal autograft did not require a reduction of t
he desired doses used for patients with postoperatively irradiated hea
d and neck cancer.