CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF A PNA-DNA COMPLEX

Authors
KASTRUP JS PILGAARD M JORGENSEN FS NIELSEN PE RASMUSSEN H
Citation
Js. Kastrup et al., CRYSTALLIZATION AND PRELIMINARY-X-RAY ANALYSIS OF A PNA-DNA COMPLEX, FEBS letters, 363(1-2), 1995, pp. 115-117
Citations number
22
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
363
Issue
1-2
Year of publication
1995
Pages
115 - 117
Database
ISI
SICI code
0014-5793(1995)363:1-2<115:CAPAOA>2.0.ZU;2-A
Abstract
Peptide nucleic acids (PNAs) are DNA mimics with a peptide backbone. P NAs are being intensely investigated owing to a potential as gene-targ eted drugs, A PNA (H-GTAGATCACT-NH2)-DNA (5'-AGTGATCTAC-3') complex ha s been crystallized in a tetragonal space group P4(1)22 with cell dime nsions a = b = 79.8, c = 99.9 Angstrom, The crystals diffract to about 5 Angstrom resolution.